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Maintaining Weight Loss After Tirzepatide: Long-Term Success Strategies Discontinuing tirzepatide without lifestyle reinforcement typically results in weight regain within 12 months, as appetite regulation and metabolic rate return to baseline biology

Collectively, these findings suggest that tirzepatide may affect OSAS severity predominantly through metabolic and inflammatory improvement, with potential adjunctive neuromuscular contributions

Insulin sensitivity starts improving

Type 2 diabetes remission rates increase sharply

When tirzepatide is used as monotherapy or with medications that do not cause hypoglycemia (such as metformin), the risk is low