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Z., McCrudden, M

Patients should also seek evaluation if they experience numbness, tingling, or color changes in fingers and toes (particularly white, blue, or red discoloration), which could indicate peripheral vascular issues or Raynaud's phenomenon rather than simple cold sensitivity

[DOI] [PMC free article] [PubMed] [Google Scholar] 138.Tuersun A., Hou G., Cheng G

[46] The activation of central neuronal GLP-1 receptors by semaglutide signals through the endogenous opioid and adrenergic systems to suppress peripheral inflammation