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For background on GLP-1 use across obesity care, see GLP-1 Weight Loss Drugs for broader context

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This triple-hormone mechanism is one of the key differences between retatrutide and other medical weight loss peptides currently available, such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GLP-1 and GIP receptor agonist), and is one reason it has attracted so much attention in clinical obesity research