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In the AWARD-11 trial, the efficacy and safety of 3.0 mg and 4.5 mg dulaglutide was evaluated at 36 and 52 weeks

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5-HT depletion does not impair the anorectic effects of leptin, which suggests that leptin does not directly cause CNS serotonin neurons to influence appetite (Lam et al., In the peripheral feed-regulating peptide, ghrelin act conversely with leptin
