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Editorial Policy Lab Results Sources verified: All PubMed citations and external references in this article were last verified onJuly 15, 2026

Participants maintaining the highest 12 mg dose of retatrutide lost an average of 30.3% of their body weight (38.5 kg) at 104 weeks, while those moving from the lowest 4 mg dose to the maximum tolerated dose lost an average of 27.9% of their body weight (33.2 kg)

These drugs were originally developed to treat type 2 diabetes, and worked by mimicking the natural hormones that lower blood sugar levels and slow down digestion

Are there risks with compounded semaglutide

These are dose-dependent and typically diminish within 48 weeks at each dose level