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When YAP is activated in organoids, it increases the expression of downstream target genes, including connective tissue growth factor ( Cgtf ) and cysteine-rich angiogenic inducer 61 ( Cyr61 )
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25,26 Therefore, starting with lower doses and a slower dose titration may help minimize this risk

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doi: 10.1007/s40618-021-01574-9 17 PurtellLSzeLLoughnanGSmithEHerzogHSainsburyAet al
The glycine and B12 rationale applies equally to both medications
