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Early reports suggested a possible increase in thyroid tumors

Taken as a once-daily oral capsule

Shorter needles, such as 5/32 in (4 mm) and 3/16 in (5 mm), are often preferred for ease of use and are suitable for most users when used with proper technique

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The success of these agents in preclinical models and clinical trials suggests a promising future for multiagonists in the treatment of metabolic diseases, with the most recent glucose-dependent insulinotropic peptide receptor:glucagon-like peptide 1 receptor:glucagon receptor (GIPR:GLP-1R:GCGR) triagonists rivaling the efficacy of bariatric surgery