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Actin is required for transport to the plasma membrane and fusion of GLP-1 secretory granules

To better understand how Tko may use inteins, we are constructing genetically modified variants with individual intein deletions to see the effects on replication strategy and cellular fitness

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In addition, the number of reported adverse events has increased each year since the introduction of semaglutide, and the number of reported adverse reactions is generally higher in women than in men (Figure 2)

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Starting with a low dose, such as 1 mg or 2 mg weekly, and gradually increasing to higher doses like 4 mg, 8 mg, or 12 mg may help reduce these effects