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Until recently, surgical procedures were considered the gold standard for effective weight loss intervention, yielding up to 3040 % body weight loss, as previously approved pharmacological inhibitors rarely yielded weight loss greater than 10 % [2]

Semaglutide is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist available by prescription only
Female mice exhibited preferential adipose tissue loss with preservation of skeletal muscle mass, accompanied by a rightward shift in fiber CSA distribution and a transition from Type IIb to Type IIx fibers, consistent with fast-twitch remodeling without functional compromise

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