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At baseline, they had an average of 4 DSM-5 alcohol use disorder symptoms (consistent with moderate severity), consumed alcohol 20/28 days and 9/28 days with heavy drinking (4+ for women and 5+ for men each day)

Some patients use these temporarily during the first 2 weeks, then discontinue as tolerance improves

Meaningful weight changes typically occur over several months, with maximal benefits observed after sustained use combined with structured lifestyle support

Studies are exploring their benefits for cardiovascular health and diabetes management