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Across the orforglipron clinical program, cases of pancreatitis have been rare and have not exceeded the background rate expected in the study populations
Clinical Trials and Safety Profile: In 2006, dipeptidyl-peptidase-4 (DPP-4) inhibitors were launched for the treatment of type 2 diabetes

The newer high-dose formulations finally make the oral route clinically relevant

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Yan X, Ma J, Liu Y, Wang X, Li S, Yan S et al (2024) Efficacy and safety of visepegenatide, a long-acting weekly GLP-1 receptor agonist as monotherapy in type 2 diabetes mellitus: a randomised, double-blind, parallel, placebo-controlled phase 3 trial
