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A 2022 warning letter from the Office of Prescription Drug Promotion (OPDP) highlighted an Instagram ad posted by the company that reportedly made, false or misleading claims and representations about the benefits and risks of Trulicity. It found that the company minimized the risks and overemphasized the benefits of the drug

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Clinicians should be aware of this potential risk [for thyroid cancer] in initiating a GLP-1 receptor agonist and carefully monitor exposed patients, especially in the presence of other risk factors for thyroid cancer, the researchers wrote.