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GLP-1 agonism blocks NLRP3 inflammasome assembly

Estradiol inhibits the activation of cell death caused by ROS (209)

Severe or recurrent genital mycotic infections and urinary tract infections warrant treatment suspension if they become problematic ( Canagliflozin specifically should be discontinued in patients with a heightened risk of amputations, including those with a history of amputations, severe peripheral neuropathy, severe peripheral arterial disease, or active lower-limb ulcers or infections, as well as in individuals with an increased fracture risk, particularly those with previous osteoporotic fractures ( 3.3 Mechanism of action of GLP1 receptor agonists GLP-1 is a hormone belonging to the incretins that is produced in the gastrointestinal tract, by L cells, in response to the intake of nutrients, especially fat and glucose ( GLP-1 RAs like liraglutide and semaglutide, offer a therapeutic advantage over native GLP-1 by being resistant to degradation by dipeptidyl peptidase-4 (DPP-4)

GLP-1 medications may actually improve menstrual regularity in women with PCOS by enhancing insulin sensitivity, promoting weight loss, and reducing androgen levels