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De Regil, World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults, JAMA , Dec
Pre-clinical findings and early retrospective data are encouraging
A third incretin-based approach is tirzepatide, a dual agonist of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR), which achieves greater HbA1c reduction and weight loss compared with GLP-1RAs alone
many, however, stringently captured HF events as secondary endpoints
On the other hand, there is some evidence of an antitumor effect of GLP-1 receptor activation in pancreatic cancer cell lines [168]
