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In recent years, autophagy, as a critical lysosome-dependent self-degradative process to maintain homeostasis, has been shown to be involved in the vascular endothelium damage in diabetes

doi: 10.4093/dmj.2012.36.4.262 97 LeeJHongS-WKimM-JMoonSJKwonHParkSEet al

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To our utter surprise, both HCQ and CQ when combined with metformin resulted in a surprising death rate in 30-40% of mice

Potential losers include medical device companies focused on diabetes care and hip and knee replacements, packaged food companies that sell candy or other unhealthy snacks and companies that sell beer and other alcoholic beverages