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About 54% were male, the median age was 60 years, and most patients were already taking other diabetes medications like metformin (76%) or insulin (52%)

Upadacitinib therapy reduces ulcerative colitis symptoms as early as day 1 of induction treatment

But some comes from people accidentally taking the wrong dose because they used the wrong concentration in their calculations

These include personal or strong family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, active or recent pancreatitis, and severe gastrointestinal disease

A temporary dose adjustment may help

Even more impressively, a pooled analysis showed that 25% to 46% of subjects with elevated baseline ALT achieved normalization by week 52, compared to only 18% of those receiving placebo