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After that, the 462 patent was also likely important to the negotiated entry date

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These patients often experience multiple comorbidities, such as diabetes and cardiovascular disease, where GLP-1 therapies offer additional health benefits beyond weight loss

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Effective Sample Size Estimation The effective sample size was calculated using the following formula: Effective sample size = N (1 annual loss to follow-up) total years , where N is the number of participants, and total years indicate the trial duration