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Peak VO 2 improvement was not supported by the pharmacokinetic/pharmacodynamic modelling, indicating no relationship between exposure to albiglutide and peak VO 2

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While the resolution of the cryo-EM map does not allow us to clearly resolve the interactions in this region, our model suggests that the exposure of the carbonyl oxygens in the backbone of Pro 6.47b -Leu-Leu 6.49b enables interactions with polar residues in TM3,5,7 that stabilize the outwards opening of the cytoplasmic half of TM6