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Nature 613 , 508518 (2023)

GLP-1 acts on insulin secretion and satiety: it increases insulin and decreases glucagon secretion, thereby blocking the endogenous production of glucose and decreasing glycemia after a meal

Scientific References MHRA authorises diabetes drug Mounjaro (tirzepatide) for weight management and weight loss

population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

But the path forward is not as simple as maintaining existing treatment

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation