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Its ability to address several aspects of diabetes pathophysiology makes it a promising treatment option

doi: 10.1093/ajcn/87.1.150

Naltrexone targets the brains reward system, while bupropion supports mood and appetite regulation

Contrave is taken as an oral tablet twice daily and has been on the market since 2014, giving it a longer safety track record

Frequent, severe, or unexplained episodes should be reviewed by a doctor, as medication doses may need adjustment

This means the peak appetite suppression with tirzepatide may take longer to achieve, but many users report that the initial onset is at least as fast, sometimes faster, likely due to the dual mechanism engaging more pathways simultaneously