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Semaglutide can cause several side effects, many of which typically become less bothersome within the first few weeks of treatment
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You trade GI problems for potential tingling, cognitive effects, and insomnia

Paracardiac adipose tissue (EAT and pericardial fat) decreased by 45 mL in the tirzepatide group ( p 30, is a significant contributor, with up to 80% of obese individuals developing MAFLD [37]
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These effects also appear to have a broader influence on metabolic health, potentially mediated through the gut microbiome
