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Whether its low or high, the blood sugar levels play an integral part in our body functions

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The model included the following covariates: age, most recent hemoglobin A1c (if available), overweight/obesity status, body mass index (BMI), hypertension, ischemic heart disease, obstructive sleep apnea, hyperlipidemia, hypercholesterolemia, and prior therapy with antidiabetic agents (including sodium-glucose cotransporter 2 (SGLT2) inhibitors, dipeptidyl peptidase 4 (DPP-4) inhibitors, thiazolidinediones, alpha-glucosidase inhibitors, sulfonylureas, metformin, insulins, and other blood glucose-lowering drugs), as shown in Supplementary Table 1

Data synthesis We conducted meta-analyses when at least two studies reported relevant outcome data

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In STEP-1 (N=1,961), 44% of participants randomized to semaglutide reported nausea compared with 18% in the placebo group [1]