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Discovery of the once-weekly glucagon-like peptide (GLP-1) analogue semaglutide

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Three factors determine how GLP-1 dosing should be interpreted: Mechanism determines biological possibility

Adequate amino acid availability is required to sustain protein synthesis, antioxidant synthesis, and metabolic homeostasis, and reductions in amino acid supply may therefore influence the capacity of redox-buffering systems that maintain oxidative stability because glutathione synthesis depends on cysteine and related amino acid precursors [78, 79]