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According to the medicines' Summary of Product Characteristics (SmPCs), no dose adjustment is generally required for patients with mild to moderate hepatic impairment

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Dehydration related to reduced food and fluid intake may contribute

Streptozotocin (STZ, initial number n = 9, final number n = 5)

In practice, if a patient is on multiple medications, the lowest effective dose of MB and close monitoring are prudent, or MB therapy might be deferred altogether if safer alternatives exist

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