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Medicinal chemistry efforts were made to understand the SAR, and one analog, WB4-24, was found to be more potent in vitro compared with Boc5

It has two mechanisms of action - both a GIP agonist and the GLP-1 agonist to work multiple pathways to aid in the potential to lose weight

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| Thomas, L., et al

doi:10.3109/10408444.2013.861798.[Taylor & Francis Online], [Web of Science ] , [Google Scholar])

The reduction in hepatic fat content was significantly higher in the combination arm vs
