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[2] [3] It is licensed in some countries including the United States and Canada for the reduction of excess abdominal fat in adults with HIV-associated lipodystrophy, but any use in the UK would be on an unlicensed basis, typically via a named patient or specials route under specialist supervision

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Despite binding to different receptors, their effects converge on protein kinases (PKA, PKB, PKC) and transcription factors like PPAR-gamma, a key regulator of lipid metabolism

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