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Orforglipron, based on trial experience, may feel rougher for sensitive GI systems, likely related to its pharmacology and rapid absorption, so if your top priority is gut calm, it may not be your first pick once available

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10.1016/j.neuropharm.2017.12.007 Neuropharmacology 72 ZhangH.ChuY.ZhengH.WangJ.SongB.SunY

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