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BCl2 is recognized for its anti-apoptotic function, whereas Bax promotes apoptosis [35]
When given to DIO mice, both peptides led to significant weight reduction, improved glucose tolerance, increased energy expenditure, and reductions in plasma cholesterol and liver steatosis
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They typically result from metabolic adaptation, hormonal changes, and behavioural factors rather than reduced medication efficacy
American College of Sports Medicine Consensus Statement
