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Keep in mind that some medications for these conditions such as insulin, sulfonylureas, or certain beta-blockers can contribute to weight gain

That clinical evidence doesn't automatically transfer to compounded preparations, which haven't been separately studied as finished products

Thus, M1 is important for the LC3B interaction, while M3 and M4/M5 modulate the WIPI2 interaction

However, biases and residual confounding inherent to EHR-based research could not be eliminated
Additional comparative evidence comes from: A 2025 narrative review synthesising randomised and indirect comparison data across obesity and type 2 diabetes trials, confirming tirzepatides superiority on weight and HbA1c [2]
