elevated lipase with glp-1 Adverse effects of class drugs. Gastrointestinal issues are GLP-1 Genetics: How Genes Affect
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![Figure][1] ### Competing Interest Statement The authors have declared no competing interest

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This review article examines the translational evolution of glucagon-like peptide-1 receptor agonists (GLP-1RAs), tracing their progression from the discovery of exendin-4 in Gila monster venom to long-acting peptide analogues and the first orally delivered peptide therapy, oral semaglutide