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W ostatnich latach nastpi gwatowny wzrost popularnoci lekw Ozempic i Wegovy, stosowanych gwnie w leczeniu cukrzycy typu 2 oraz jako rodki wspomagajce odchudzanie
Using an integrated ligand and structure-based virtual screening pipeline, explicitly combining complementary ligand-based descriptors, multi-fingerprint similarity, electrostatic similarity, pharmacophore modeling, and multi-conformation docking under a consensus-driven selection strategy, we were able to identify three chemically distinct classes of GLP-1R agonist candidates: GQB47810, a non-peptidic molecule
What to expect while on GLP-1 treatment
Conclusion Our findings showed a benefit of GLP-1 RAs on HHF and all-cause death in patients with diabetes regardless of HF history
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