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The highest dose (2.4 mg of each agonist) decreased body weight in participants with overweight by 17% in 20 weeks 90

According to research on medication routes of administration, when medications dissolve under the tongue or in the cheek, they undergo passive diffusion through the venous blood in the oral cavity, which bypasses the hepatic portal vein and flows directly into systemic circulation

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Hasan AA, von Websky K, Reichetzeder C, et al

doi: 10.1016/0014-5793(91)80182-3

It is clarified that guanfacine is not a prohibited substance