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Using an integrated ligand and structure-based virtual screening pipeline, explicitly combining complementary ligand-based descriptors, multi-fingerprint similarity, electrostatic similarity, pharmacophore modeling, and multi-conformation docking under a consensus-driven selection strategy, we were able to identify three chemically distinct classes of GLP-1R agonist candidates: GQB47810, a non-peptidic molecule

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“Millions of Americans could benefit from GLP-1s, but clinical trials suggest patients need to stay on these drugs to experience sustained benefits,&rdquo

As GLP-1 therapies continue to redefine chronic care, dependable containment becomes an essential part of treatment success

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