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The good news is that GLP-1 constipation is usually manageable
The 2025 J Clin Med: The Cleanest Lens Yet A February 2025 study in Journal of Clinical Medicine offered one of the most controlled evaluations to date

Gastrointestinal side effects represent one of the most common challenges when starting GLP-1 receptor agonist therapy, with diarrhea occurring in approximately one-quarter of patients during initial dose escalation

[DOI] [PubMed] [Google Scholar] 2.Kimball CP, Murlin JR

The outcome of this motion could affect many of the 1,500+ cases pending in the federal multidistrict litigation

Cell bodies of PPG neurons also have been described in the adjacent medullary reticular formation, both in rodents, non-human primates, and humans [21,22,23,24,25,26], as well as in a small population of glutamatergic olfactory bulb interneurons that express PPG that can modulate the firing pattern of the mitral cells in rodents [13,22,23,27,28]