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About 21% of the cohort had sufficient electronic health record data to determine contraception overlap with the period of GLP-1 RA initiation
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New prescriptions accounted for 76% of the citys April spending on GLP-1 drugs used for weight loss, the report said
For example, most major GLP-1 trials have enrolled people with obesity or diabetes
GLP-1 receptor activation in pancreatic beta cells promotes glucose-dependent insulin secretion and suppresses glucagon release, while central GLP-1 receptor activation in hypothalamic appetite centers reduces food intake and promotes satiety
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