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Importantly Exendin-4 has a mutation that blocks its cleavage extending its half-life to 2.4 h
Exenatide inhibits the growth of endometrial cancer ishikawa xenografts in nude mice

Retatrutide may be stronger for weight loss based on trial results so far, but Mounjaro is currently the better treatment option for most eligible UK patients because it is approved and available

We know it as a building block for muscle and a tool to blunt blood sugar response

Clinical response varies based on genetics, baseline metabolic rate, gut hormone sensitivity, and GLP-1 receptor expression

The therapeutic potential of GLP-1 has led to the development of GLP-1RAs, which mimic its effects [11]
