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Riddle MC, Cefalu WT, Evans PH, Gerstein HC, Nauck MA, Oh WK, Rothberg AE, le Roux CW, Rubino F, Schauer P, et al

Large increases in exercise above an individuals typical weekly level are associated with higher minimum heart rate , suggesting increased physiological strain

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Sun et al., 2021)

Following this, Thorens needed to verify its activity which he did by introducing the coding sequence into various cells

Hadjyanni et al