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The mechanism of action of GLP-1 RAs includes enhancing glucose-dependent insulin secretion, suppressing glucagon release, reducing appetite, and slowing gastric emptying through vagally mediated pathways [3, 4]

Use In Specific Populations Pregnancy Risk Summary All pregnancies have a background risk of birth defects, loss, or other adverse outcome regardless of drug exposure

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Gegen Qinlian decoction ameliorates insulin resistance in type 2 diabetes: A systematic review and meta-analysis of RCTs with mechanistic insights into SIRT1/AMPK pathway activation

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But natural GLP-1 peaks at roughly 59 pg/mL and degrades within minutes, while prescription semaglutide sustains levels around 65 ng/mL for days
