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But even as they lost weight, they didnt feel better

Usually, the left heart will have higher pressures than the right heart, but if the right heart pressure exceeds the left, then de-oxygenated venous blood can bypass the pulmonary circulation and enter the left heart and systemic circulation, causing hypoxemia

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Allergic reactions : Serious reactions, like swelling or difficulty breathing, may occur

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More recent studies evaluating higher doses of semaglutide have reported average weight reductions of around 20% over about 72 weeks in people with obesity