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The mean follow-up time was 160.5 18.4 days for the semaglutide group and 150.2 26.8 days for the non-GLP1R agonist anti-obesity medication group

Patients with a history of gastroparesis, severe gastrointestinal disease, or inflammatory bowel disease require careful evaluation, as delayed gastric emptying induced by semaglutide may potentially worsen symptoms or interfere with the absorption of other medications

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The 9mg dose deserves particular attention for OA patients: 75.8% pain reduction at half the dysesthesia burden of 12mg (8.8% vs 20.9%), with 26.4% average weight loss

Integrated medical approaches have shown great success, especially for those with severe obesity or complex needs

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