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Although GLP-1s arent indicated to treat RA, they've been given to patients who have rheumatoid arthritis and a comorbidity such as obesity or diabetes

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Replacing GLP-1 Gln 23 with Ala slightly lowered the affinity and activity (IC 50 : 0.27 nM1.1 nM

While researchers dont fully understand why semaglutide causes constipation, both slower gut motility and changes in diet are likely contributors

doi: 10.1523/JNEUROSCI.0529-11.2011 [DOI] [PMC free article] [PubMed] [Google Scholar] 176

The FDA uses vitamin C (ascorbic acid) as an example to explain that: it can come from an orange or be produced in a laboratory the end molecule is the same