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While first-gen GLP-1s were optimised for the pancreas, next-gen therapies like KP405 are engineered to reach brain tissue directly

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The rates of major abdominal surgery were comparable between groups, and there was no sign of increased surgical risk

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The RID FP (%) values reflect the slow, stable release profile of semaglutide over the dosing period

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2023: Tirezepatide (Zepbound) receives FDA approval for weight loss

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