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Curr Obes Rep 10(4):458466 Rentzeperi E et al (2022) Sex Differences in response to treatment with glucagon-like peptide 1 receptor agonists: opportunities for a tailored approach to diabetes and obesity care

Examples include: kidney problems, such as kidney failure low blood sugar pancreatitis (swelling of your pancreas) gallbladder disease, which may include cholecystitis (swelling of your gallbladder) or gallstones severe digestive problems (such as nausea, vomiting, or diarrhea), which, in severe cases, can lead to dehydration and result in severe kidney injury risk of thyroid cancer Note: Ozempic has a boxed warning for the risk of thyroid cancer

McCall McPhereson: Yeah, huge

While the FDA updated Ozempics label to include some gastrointestinal risks in 2023, for many, this warning came far too late and did not go into enough detail

Signs and symptoms of low blood sugar may include dizziness or light-headedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, or feeling jittery dehydration leading to kidney problems

For our US market forecasts, pricing dynamics are the single biggest swing factor