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Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH

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Groups were as follows: saline/control antibody ( n = 8), Saline/-MSTN + -ActA ( n = 7), Sema/control antibody ( n = 7), and Sema /-MSTN + -ActA ( n = 8)

Intraventricular administration of streptozotocin (STZ) is considered a model of sporadic AD, though data on hypothalamic glial cell changes, ependymal glia, and tanycytes in this model remain limited

These usually improve as dosing stabilizes

GIP, or glucose-dependent insulinotropic polypeptide, is the other major incretin hormone