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Additionally, the administration of LPS (endotoxin) into the peritoneum of rats resulted in notable damage to the peritoneal mesothelial layer, increasing its permeability and suggesting that inflammatory signaling serves a key role in PD failure (Fig

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J Mol Med 91:951963 Linfoot P, Bergstrom C, Ipp E (2005) Pathophysiology of ketoacidosis in Type 2 diabetes mellitus

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Whereas DHEAS is the most abundant circulating steroid hormone in the human body [181], rats and mice (the species typically studied) have low circulating concentrations of DHEA(S) in the periphery [71