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No treatment-related AEs were reported in the severe renal impairment group

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In 2024, thrombosis of the central venous catheter occurred, necessitating anticoagulant therapy with apixaban (2.5 mg twice daily)

One technical detail that may explain the sustained efficacy: tirzepatide has biased agonism at the GIP receptor, favoring G-protein signaling over beta-arrestin recruitment

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