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Excess visceral fat produces aromatase, an enzyme that converts testosterone into estrogen

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In response to significant and/or high-nutrient meals, GLP-1 reaches high blood concentrations, exerting its effects on GLP-1Rs located in the area postrema, the nucleus tractus solitarius, and the hypothalamus

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In this review, we will summarize the proposed underlying mechanisms of exercise intolerance in patients with HFpEF