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Estradiol indirectly increases POMC activity through its effects on NPY/AgRP neurons (82, 83)

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The group was reviewing a paper on tirzepatide, a GLP-1 agonist, which reported that the drugs efficacy for weight loss was nearly comparable to that of bariatric surgery

As a general principle, it takes approximately five half-lives for a medication to be considered essentially eliminated from the body (representing about 97% clearance)

[ Lancet