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Semaglutide: Semaglutide is a revolutionary GLP-1 receptor agonist that has garnered significant attention for its effectiveness in managing obesity and type 2 diabetes

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Moreover, peptide analogues that are unimolecular co-agonists of both GLP-1R and GCGR are currently in clinical development for the treatment of T2D, obesity and non-alcoholic steatohepatitis (NASH) 2,3,5,6,7

When cortisol stays elevated, it can interfere with the SCFA-driven signals and the circadian timing that normally support healthy GLP-1 activity, which may leave appetite harder to regulate