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glp-1 drug delivery devices Battle of technologies Driving GLP‑1 Drug Delivery &
Description
A proposal for validation of antibodies
Solid clinical proof of slowed diabetes progression or enhanced -cell mass has not been provided in type-2 diabetic patients treated with any GLP-1 receptor agonist [549]
For manufacturers, this presents a dilemma
They are 463 amino acid heptahelical G protein-coupled receptors that, when activated, stimulate cyclic adenosine monophosphate (cAMP) formation followed by activation of protein kinase A pathways [20]
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J Biol Chem (2003) 278:4718
